This is what the first six months on a weekly weight loss shot like semaglutide or tirzepatide usually look like, written the way we'd tell you on the phone. Everybody is a little different and your provider sets your actual plan, but the shape of it is pretty consistent and knowing it in advance is most of what keeps people from quitting in week two.
General information, not medical advice · your dose and your plan are set by your provider · text us anytime at 561-216-7066
Medically reviewed by Gabrielle Radabaugh, APRN, FNP-C, autonomous practice nurse practitioner, licensed by the Florida Board of Nursing, license number APRN11021890. Reviewed October 5, 2026. Gabrielle is the founder of Beyond Concierge Healthcare and the provider responsible for the clinical content on this page. Read more about Gabby.
Almost nobody feels dramatic in week one, and that trips people up because they're braced for something. The starting dose is deliberately low. It's there to let your body get used to the medication, not to produce a result, and that's why your provider starts you there instead of where you'll eventually land.
You take your first shot, usually on a day of the week you can stick to. Most people feel very little. Some people notice they get full faster at dinner by day three or four, and some notice nothing at all, and neither of those means it's working or not working. Mild nausea, a bit of burping, or feeling off for a day after the shot are the common early complaints, and they're usually mild at this dose.
This is where most people first notice the thing everybody describes as the food noise going quiet. You stop thinking about the kitchen. Portions you used to finish start feeling like too much halfway through. The scale may or may not have moved yet and that's normal.
Appetite is usually clearly down by now and the scale is usually moving, often a pound or two a week. This is also where the mistake happens: people eat so little that they feel wiped out. If you're exhausted, you're probably underfed and underhydrated rather than reacting badly to the medication, and this is a good week to text us.
End of your first month, and your provider looks at where you are. If you're tolerating it and the weight is moving at a sensible pace, your dose may stay put. If appetite has stopped being affected, your dose usually goes up. Dose increases are typically considered about every four weeks, and they're a decision your provider makes rather than something that happens automatically.
The side effects people actually report are digestive, they cluster in the first few days after a dose and in the week or two after a dose increase, and they get better as your body adapts. Most of them are manageable with how you eat rather than with another prescription.
The thing worth knowing is that a side effect is usually a reason to adjust, not a reason to stop. Most of what we do in month one and two is slow somebody's dose down or hold it steady a few extra weeks so they can stay on it, because the people who get a result are the people who are still on it in month six.
Months two and three are the steady part. You're usually on a dose that's doing something, the side effects have settled, and the weight comes off at a pace that looks boring on a week to week basis and significant on a month to month one. Somewhere between half a pound and two pounds a week is the range most people live in, and slower than that is not failure.
What matters more in this stretch than the number on the scale is what you're eating, because this is the window where you either build the habits that hold the result or you don't. Your meal plan is there for this.
By month four most people are at or near the dose they'll stay on, and the conversation shifts from getting started to where this is going. Published trial results for the weekly GLP-1 medications land in the range of roughly ten to fifteen percent of body weight for semaglutide and roughly fifteen to twenty percent for tirzepatide over a year or more, and real people land all over that range and sometimes outside it. Nobody can promise you a number and we won't.
What your provider is doing in this stretch is deciding whether you keep climbing, hold where you are, or start thinking about maintenance. If you've stopped responding, that's the point where we'd talk about switching medications rather than just adding dose.
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Usually very little, and that's by design. The starting dose is low so your body can get used to the medication. Some people notice they get full faster within a few days, some notice nothing, and mild nausea or feeling off for a day after the shot is the common early complaint.
Most people see the scale move somewhere in weeks two to four, often a pound or two a week once appetite is clearly down. Some people lose nothing in the first month and then respond well once the dose goes up, which is why a slow start isn't a reason to quit.
They cluster in the first few days after a dose and in the week or two after a dose increase, and they usually settle as your body adapts. Nausea and constipation are the common ones. If a side effect isn't manageable, the usual answer is to hold or lower the dose rather than stop the program.
Commonly somewhere between two and eight pounds, and a fair number of people lose less than that in month one and then do well later. Month one is mostly about getting on the medication and tolerating it, not about the result.
Dose increases are typically considered about every four weeks, and it's your provider's decision based on how you're tolerating it and whether the current dose is still working. It doesn't happen automatically on a schedule.
Protein at every meal, smaller portions, slower eating, and a lot more water than you think you need. You're eating much less so what you eat has to carry more, and protein plus resistance training is what protects your muscle while you lose. Your meal plan is included in your first month.
Stalls of a week or two are normal and almost never mean the medication stopped working. A stall that runs six to eight weeks at a steady dose is worth a real conversation with your provider, and the answer is sometimes a dose change and sometimes a different medication.
Published results for the weekly GLP-1 medications run roughly ten to fifteen percent of body weight for semaglutide and roughly fifteen to twenty percent for tirzepatide over a year or more. Individual results vary a lot and no specific outcome is promised.
Appetite generally comes back, and most people regain a meaningful portion of the weight if nothing else changed. That's why maintenance is its own plan, usually at a lower dose, and why we push resistance training and protein from month two on.
Five pages and the main one, and between them they answer just about everything people ask us before they book.
The main page. What the program is, which medications we prescribe, and how to start.
Read this →Every number on one page. $375 for month one and from $299 after that, with nothing hidden behind it.
Read this →The whole thing start to finish, from the form you fill out to the medication landing on your doorstep.
Read this →An honest look at how we compare to Hims, Ro and Found, including where they beat us.
Read this →Who we can prescribe for, who we can't, and what the provider is looking at on your first visit.
Read this →One visit, $375, and a provider who is still picking up the phone in month six. Anywhere in Florida.
Beyond Concierge Healthcare is a Florida medical practice. All treatment is provided by licensed Florida clinicians after a medical evaluation, and no medication is prescribed without one. Medical weight loss is provided by telehealth to patients located anywhere in the State of Florida. Semaglutide, tirzepatide and the oral appetite suppression medications described on this page are prescription products and are not appropriate for everyone. Compounded medications are not FDA approved products and are not reviewed by the FDA for safety or effectiveness. Individual results vary and no specific outcome is promised. This page is general information and is not medical advice, and it is not a substitute for an evaluation by your own clinician. Prices shown are current as of the date of publication and are subject to change. Prescribed or shipped medication cannot be returned or refunded. If you are experiencing a medical emergency, call 911.